Beginning in 1965, de Ville denoted Cadillac's mainstream model, falling between the Calais and the Fleetwood.
All GM fullsize lines were completely redesigned for 1965, yet de Ville retained its 129.5-inch (3,290 mm) wheelbase. The Series 62 on which the de Ville was based was now called Calais. Rounded body styling gave way for sharp, angled lines. Tailfins disappeared, and headlights were now stacked vertically allowing for a wider grille. The pillared sedan variant returned. Power was still supplied by the 429 cu in (7,030 cc) V8, which was replaced by the 472 cu in (7,730 cc) for 1968.
For 1968, the de Ville gained slight exterior changes to comply with new federal safety and emissions legislation, and as with the rest of the Cadillac lineup, a new 472 cu in (7,730 cc) V8 engine rated at 375 hp (SAE gross). 1968 was also the last year for the "stacked" dual headlights, which were replaced with side-by-side dual headlights in 1969.